浙江大学爱丁堡大学联合学院2019年博士后招聘公告（30 万年薪）

浙江大学爱丁堡大学联合学院（ZJE）坐落于浙江大学海宁国际校区，是由浙江大学（2019QS世界排名第54位）和英国爱丁堡大学（2019QS世界排名第20位）合作成立的非独立法人中外合作办学机构，专注于探索“生物-医学-信息-工程”学科交叉研究。

The Zhejiang University-University of Edinburgh Institute (ZJE) is based in state of the art facilities at the new International Campus in Haining, Zhejiang, P.R.China. The new Institute, established by two world-leading universities, Zhejiang University and University of Edinburgh, is focused on international Biomedical Sciences/Bioinformatics/Biomedical Informatics/Biomedical Engineer research collaboration.

 

ZJE正与浙江大学医学院附属第二医院开展战略合作，探索以疾病诊疗为导向的生物医学前沿联合研究。

ZJE is carrying out strategic cooperation with the Second Affiliated Hospital of Zhejiang University School of Medicine to explore frontier research on biomedical sciences oriented by disease diagnosis and treatment.

 

了解更多信息，请查阅以下网址：

To learn more information about the institute, please refer to the websites below:

http://zje.zju.edu.cn (ZJE, 浙江大学爱丁堡大学联合学院)

http://www.intl.zju.edu.cn (International Campus, ZJU, 浙江大学海宁国际校区)

http://www.zju.edu.cn (Zhejiang University，浙江大学)

https://www.ed.ac.uk (the University of Edinburgh，爱丁堡大学)

http://www.z2hospital.com (the Second Affiliated School of Zhejiang University School of Medicine，浙江大学医学院附属第二医院)

WHAT WE ARE LOOKING FOR

ZJE面向全球诚聘博士后研究人员，学科领域涵盖干细胞和再生医学、免疫学、生物化学和分子生物学、细胞生物学和病原微生物学等。

ZJE is now seeking applications for postdoctoral positions from around the world. Research themes include: Stem Cell and Regenerative Medicine, Immunology, Biochemistry and Molecular Biology, Cellular Biology, Pathogenic Microbiology.

申请者需拥有生物学、医学、生物医学、生物信息学和公共健康等相关领域博士学位，已在国际刊物上发表过较好研究论文者优先考虑。

Applicants will be expected to have a PhD in biology, medical science, biomedical science, bioinformatics, public health or a related field and show evidence of their research achievements and potential.

 

欧阳宏伟Hongwei Ouyang: hwoy@zju.edu.cn

个人主页Website: http://person.zju.edu.cn/en/ouyanghongwei

研究领域Research:

欧阳宏伟教授长期从事干细胞与骨、软骨、肌腱组织的再生研究，先后获批国家级、省部级科研项目近20项。

Prof. Ouyang Hongwei focuses on the research of stem cell and regenerative medicine, sports medicine, tissue engineering and biomedical materials.

 

黄雯雯Wenwen Huang: wenwenhuang@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/wenwenhuang

研究领域Research:

本课题组致力于设计开发具有特定功能的人造蛋白材料，以满足当前资源、能源、环境等可持续发展策略对新材料的迫切需求。本实验室通过将生物物理、生物工程以及医学等领域进行交叉融合，建立了以蛋白功能为导向、以生物合成和多尺度模拟为基础、以高通量制备分析和功能测试为验证和优化手段的人造蛋白功能材料创制体系。主要研究方向为（1）蛋白质序列-结构-功能的关系以及蛋白质材料对人体组织/细胞生长分化的影响；（2）智能蛋白质材料设计、高通量筛选、蛋白质自组装理论研究和蛋白质材料物理化学改性；（3）蛋白质基柔性电子设备研发等应用方面的研究工作。

Dr. Huang’s lab focuses on predictive design, synthesis and functionalization of protein-based biomaterials for regenerative medicine and sustainable bio-electronics. Current research projects include: (1) injectable hydrogel and stem cell engineering, (2) stimuli-responsive biomaterial design, and (3) flexible electronics. Postdoc positions are available for highly motivated candidates with expertise in synthetic biology, material science and stem cell engineering.

 

刘琬璐Wanlu Liu: wanluliu@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/labw

研究领域Research:

本课题组通过多学科交叉，结合基因组学(RNA-seq, Bisulfite sequencing, ChIP-seq, ATAC-seq, Hi-C, single cell-based sequencing)、分子生物学以及生物信息学，来研究表观遗传在调控细胞 命运决定过程中的起到的在基础科学层面以及临床转化方面相关的问题。主要的研究方向包括:1)研究转座子在细胞命运决定过程中涉及的表观遗传调控相关问题。2)开发用于预测细胞命运的基于机器学习/深度学习相关的基因组学算法。3) 基于表观遗传组学的疾病分型以及疾病预测。

1) understand the epigenetic basis of transposable elements in cell fate descisions. 2) develop machine learning based algorithm to predict cell fate.

 

陈迪Di Chen: dichen@intl.zju.edu.cn

个人主页Website: http://labchen.cn

研究领域Research:

陈迪博士的实验室研究人类胚胎发育和胚胎干细胞分化的调控。目前，陈迪实验室招聘数位博后，主要研究课题包括：

（1）人类胚胎干细胞分化在表观遗传层面以及转录后层面的调控。

（2）RNA-结合蛋白在人类原始生殖细胞诱导和分化过程中的功能。

（3）决定细胞命运的转录因子在人类胚胎干细胞分化过程中的新功能。

Dr. Chen’s lab focuses on the regulation of human embryogenesis and embryonic stem cell differentiation. Postdoc positions are available in Chen lab for the following projects

(1) The regulation of human embryonic stem cell differentiation at epigenetic and post-transcriptional levels.

(2) The function of RNA-binding protein during human primordial germ cell specification and differentiation.

(3) The new functions of cell fate determinant transcription factors during embryonic stem cell differentiation.

 

Sebastian Leptihn: leptihn@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/en/H118035

研究领域Research: The Leptihn Group offers two Postdoctoral Fellowships; one project focusses on the investigation of membrane proteins controlling cellular signalling pathways employing microfluidics and single molecule methods (fluorescence, electrophysiology) together with the University of Edinburgh and the ZJUI (Zhejiang University-University of Illinois Urbana Champagne). The second project involves viruses of microbes (bacteriophages) with aspects on both, function and structure of phage proteins, as well as phage therapy. Experience in imaging and protein biochemistry or microbiology are desired.

 

洪智Zhi Hong: zhihong@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/en/hongzhi

研究领域Research:

本课题组将从细胞器交流角度解析细胞-外界环境的相互作用，即外界环境变化（特指外源的能量供给变化）对细胞器互作结构特质（property）/稳态（homeostasis）的影响。直接研究方向主要集中在两个方面：1）结合领域内已知和本人的前期数据，对细胞器互作网络改变细胞器膜脂组成和蛋白成分进行深入的机制研究。2）利用新的生物标记或技术从亚细胞器水平上发现细胞器互作网络对单个细胞器的影响，进一步拓展我们对细胞器互作网络的功能认知。

1. The regulation of organelle-organelle crosstalk on biogenesis-maturation- location of organelles.

2. The function or contribution of organelle-organelle crosstalk in stress response.

Sue Welburn: sue.welburn@ed.ac.uk

个人主页Website:http://www.ed.ac.uk/pathway-medicine/our-staff/staff-profiles/profsuewelburn

研究领域Research:

Sue focuses on interventions for disease control in the Global South, with on-going projects in Kenya, Morocco, Mozambique, Tanzania, Uganda, Nigeria, Zambia and Zanzibar.

 

鲁林荣Linrong Lu：lu_linrong@zju.edu.cn

个人主页Website: http://person.zju.edu.cn/en/llr

研究领域Research:

本实验室旨在用分子生物学、细胞生物学和实验动物模型等研究手段揭示免疫调节的机制。尤其对胸腺T细胞发育、CD8+ T细胞亚群和具有免疫调节功能新分子的研究感兴趣，同时对自身免疫性疾病和肿瘤的免疫治疗的策略进行研究。

研究手段：分子生物学，细胞培养，基因敲除，自身免疫性疾病动物模型

正在开展的课题：

1）CD8+ T细胞亚群与自身免疫性疾病与抗肿瘤免疫

2）胸腺T细胞的发育分化

3）T细胞分化的信号传导调控

4）固有免疫的信号传导和基因表达调控

The main focus of our lab is to elucidate the molecular pathways and cellular interactions that mediate and regulate thymocyte development and T cell-mediated immune responses by using molecular biology and genetic approaches. We are especially interested in the identification and characterization of novel immune-related molecules and the development and treatment of autoimmune diseases.

 

郭伟Wei Guo: weiguo@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/en/gwlab

研究领域Research:

郭博士从事干细胞和癌症的研究，精于人类和小鼠遗传学，分子生物学，细胞生物学，生物医学，及基因组学的方法。他在造血发育、白血病干细胞以及肿瘤耐药调控方面等有重要建树。他建立了第一个由PTEN缺失导致T细胞急性白血病的小鼠模型，促成临床发现只带有PTEN突变而没有NOTCH1突变的婴幼儿T细胞白血病病人。他首次分离了T细胞急性白血病干细胞，揭示出了多因子突变导致白血病干细胞形成的过程，并发现了mTOR抑制剂的双重抗癌机制。近来，郭博士课题组从临床肺肿瘤中分离出肿瘤干细胞，并发现NOTCH1信号通路调控肺肿瘤干细胞的自我更新和铂类耐药。

Dr. Wei Guo laboratory uses basic biological approaches to understand biomedical challenges and translates its understanding to clinical practice. There are two major research directions: (1) stress response and ex vivo expansion of hematopoietic stem cells; and (2) regulation and targeted inhibition of cancer resistance.

 

谢昕Xin Xie: xinxie@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/en/xinxie

研究领域:

研究方向：课题组运用分子生物学、细胞生物学、生物信息学、3D类器官培养和转基因小鼠模型研究干细胞命运控制，衰老及相关疾病的靶向治疗。

正在开展的课题：

1）肠干细胞稳态平衡、恶性转化及肠道疾病的早期诊疗。运用生物信息学分析、小鼠模型和肠道类器官，我们将深入研究大肠肿瘤干细胞的恶性转化和肿瘤转移的分子机制，并开展临床转化研究。

2）干细胞发育、衰老和融合的信号调控。实验室的最新成果揭示了首个永久性的阻断体内细胞融合的动物模型。在此基础上，我们将进一步探讨细胞融合与衰老的分子机理。

3）肌肉萎缩症，糖尿病和肥胖的靶向治疗。实验室已发表的研究证实了新的疾病治疗靶点。为此，我们将运用高通量筛选实验找寻靶点基因的小分子抑制剂，进行临床前期研究。

We investigate signaling molecules within adult stem cells (intestinal、muscle and mesenchymal stem cells) regulate their fundamental properties in both physiological and pathological conditions.

Research interest: adult stem cell and related disorders

1. Intestinal stem cell, colorectal cancer and inflammatory bowel disease

2. Mesenchymal stem cell, muscle stem cell, musculoskeletal disorders and metabolic syndrome

 

Mikael Bjorklund: mikaelbj@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/en/H118035

研究领域Research:

本实验室主攻癌症细胞生物学，致力于肿瘤细胞生长和代谢(参见我们的论文《Dev Cell, 2016》，《Trends in Cell Biology, 2017》)。我们使用定量和基因组数据来了解细胞大小、细胞生长和代谢之间的关系。我们实验室在热蛋白组学分析处于前沿行列（参见我们的论文《EMBO J, 2018》），并以此技术来研究药物和代谢物与细胞蛋白之间的相互作用。我们的项目结合了信息学和实验细胞生物学，因此我们非常欢迎来自不同科学背景的候选人提出申请。具有生物信息学、计算机科学或物理学背景者将优先考虑。

Mikael Bjorklund lab works on cancer cell biology, focusing on cell growth and metabolism (Dev Cell, 2016; EMBO J, 2018). The main interest in the laboratory is how metabolism, particularly mitochondria, and cell size impact cellular fitness and functions.

 

Ting Gang Chew: tinggchew@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/en/H118023

研究领域Research:

细胞通过感知和转导机械力信号来产生恰当的胞内生物化学应答。细胞内外的机械力都有助于胞质分裂的成功，从而使一个细胞分裂为两个子细胞。研究表明细胞胞质分裂的失败与基因组不稳定性、肿瘤进化和衰老紧密关联，而胞质分裂的成功则与细胞动力学和细胞外基质的相互作用密切相关。我们的研究目的是探究胞质分裂在衰老或其它病理状况下的对细胞外基质不同刚度反应的机械力学和动力学机制。为此，我的实验室联合采用化学遗传学、光遗传学和高分辨率活细胞显微成像技术探究胞质分裂失败产生的结果和胞质分裂的机械生物学机制。

Cells sense and transduce mechanical signals to generate appropriate biochemical and cellular response. Both the cellular and extracellular mechanics contribute to the success of cytokinesis, which is the division of one cell into two. Failure of cytokinesis is implicated in genomic instability, tumor evolution, and aging. The success of cytokinesis is linked to the proper interaction of cytokinetic machinery and the extracellular matrix. We aim to study the mechanics and dynamics of cytokinesis in response to different extracellular matrix stiffness during aging or other pathological conditions. To this end, my lab couple chemical genetics, optogenetics and high resolution live cell microscopy imaging to study the mechanobiology of cytokinesis and the consequences of its failure.

 

王超尘Chaochen Wang： chaochenwang@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/en/H118068

研究领域Research:

实验室充分利用高通量测序，以CRISPR介导的基因编辑和表观遗传编辑为主要技术手段，结合生物信息学分析,  充分结合基因组学、表观遗传学、信息学、基因编辑技术和动物体内筛选模型，致力于以临床疾病为导向的表观遗传学方向的研究。研究方向分为基础和临床研究两个部分，并相互交叉。

实验室目前主要研究方向包括：

1）细胞命运改变的表观遗传调控机制研究

2）基因编辑及表观遗传编辑工具研究

3）乳腺发育及乳腺癌发生的分子机制及免疫调节机制研究

Dr Chaochen Wang’s lab focuses on dissecting the molecular mechanisms underlying the cell fate transition during ESC differentiation, mammary gland development and tumorigenesis. Leveraging CRISPR-mediated genome and epigenome engineering tools, NGS and bioinformatics, his lab aims for making prominent impact on stem cell study, cancer diagnosis and prognosis in a long run.

 

Kuan Yoow Chan: kychan@intl.zju.edu.cn

个人主页Website: https://person.zju.edu.cn/en/H118031

研究领域Research:

The centrosome is an important signalling and microtubule organizing centre in mammalian cells. Centrosomal defects are a common in high grade cancer and have been shown to trigger tumorigenesis in mice. The impact of centrosomal defects in deregulating the cell cycle in cancer is poorly understood. In addition, cancer genome sequencing efforts worldwide show mutations on centrosomal components are common. Using genetic, cell biology and biochemical assays, we aim to study how the changes in centrosomal signalling lead to the deregulation of the cell cycle in cancer.

应聘者将与浙江大学签订合同，工作地点为海宁国际校区。

The posts will be located at ZJE Institute in Haining and the contract of employment will be held with Zhejiang University.

薪资及待遇Salary and Benefits

1）薪资待遇参照浙江大学博士后招聘相关政策执行，年薪最高可达人民币30万元。

Salary is commensurate with qualifications and experience, compliant with policies for postdoctoral recruitment in Zhejiang University. Annual pay is in the region of 300,000 RMB.

2）学校有偿提供教师公寓（优惠价格租赁）、支持申请国家自然科学基金，鼓励支持在站期间申报各类博士后基金和国际交流专项计划资助。

Postdoc Fellows is eligible to rent staff apartments at favorable price, and is encouraged to apply for NSFC、Postdoctoral Funding and International Exchange Funding.

3）ZJE为博士后研究人员提供国际化科研环境以及国际学术交流的机会。

ZJE provides an excellent research environment and opportunities for international academic exchange.

HOW TO APPLY

1） 简历Your CV

2）学历学位证书Certificates of education experience

3）科研经历和学术成就简述A summary of your research experience to date

4）2封推荐信（其中一封来自博士期间导师）Two references from experts in your scientific field (one from your PhD supervisor)